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CEP: Process Safety Beacon - Valve Actuator Rupture Incidents

Process Safety Beacon
November
2010
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Stem Cell Engineering 101

Stem cells are poised to transform medical treatments for a host of diseases and malignant conditions. Translating stem cell research into clinical therapies, disease models, and drug-screening platforms will require a combination of sound science and innovative chemical and biological engineering.

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Integrating mesenchymal stem cells and biomaterials shows promise for treating traumatic skeletal injuries via bone tissue engineering.

Scaling Up Research to Commercial Manufacturing

The production of stem-cell-based therapeutic products in large quantities is more complex than manufacturing molecular drugs. Scale-up and scale-out challenges arise related to the type of stem cell, cell expansion and banking, sterile handling, culture media, cell harvesting and concentration, and...

Developing Cell Therapy Biomanufacturing Processes

Establishing scalable technology platforms that allow for varying levels of production throughout the different stages of clinical testing can minimize process development timelines, drug-comparability risks, and 鈥� ultimately 鈥� costs.

SBE Update: The Engineering of Stem Cells

Understand Heat Flux Limitations on Reboiler Design

Avoid the transition to film boiling to obtain better control and lower operating costs.

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